Population-based 3D genome structure analysis reveals driving forces in spatial genome organization
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چکیده
منابع مشابه
Population-based 3D genome structure analysis reveals driving forces in spatial genome organization.
Conformation capture technologies (e.g., Hi-C) chart physical interactions between chromatin regions on a genome-wide scale. However, the structural variability of the genome between cells poses a great challenge to interpreting ensemble-averaged Hi-C data, particularly for long-range and interchromosomal interactions. Here, we present a probabilistic approach for deconvoluting Hi-C data into a...
متن کاملSUPPORTING INFORMATION SI Appendix for: Population–based 3D genome structure analysis reveals driving forces in spatial genome organization
Population–based 3D genome structure analysis reveals driving forces in spatial genome organization Harianto Tjong, Wenyuan Li, Reza Kalhor, Chao Dai, Shengli Hao, Ke Gong, Yonggang Zhou, Haochen Li, Xianghong Jasmine Zhou, Mark A. Le Gros, Carolyn A. Larabell, Lin Chen, and Frank Alber Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, 10...
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DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...
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The spatial organization of genomes is non-random, cell-type specific, and has been linked to cellular function. The investigation of spatial organization has traditionally relied extensively on fluorescence microscopy. The validity of the imaging methods used to probe spatial genome organization often depends on the accuracy and precision of distance measurements. Imaging-based measurements ma...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1512577113